The core process of Freeze-Dried Powder OEM covers the entire chain of collaboration from raw material preparation to finished product delivery, which can be divided into the following key stages:

I. Raw Material Screening and Pre-treatment

Material Selection

Screening active ingredients based on product positioning (such as probiotic freeze-dried powder or cosmetic freeze-dried powder), such as Lactobacillus, Bifidobacterium, peptides, growth factors, etc., paired with excipients (e.g., mannitol, maltodextrin) and stabilizers.

Raw materials must comply with food safety or cosmetic ingredient standards. For example, probiotics need to be tested for live bacteria count and impurity content, while cosmetic ingredients must pass heavy metal and microbial tests.

Acceptance and Activation

Each batch of raw materials undergoes sensory (appearance, odor) and physicochemical (moisture, pH) testing to ensure compliance with production requirements.

Active ingredients undergo activation treatment (e.g., probiotics need to be revived at specific temperatures and in specific culture media) to restore their biological activity.

Pre-mixing and Low-temperature Pulverization

The active ingredients and auxiliary materials are initially mixed to avoid clumping, then ground into fine powder using low-temperature pulverization technology to prevent high temperatures from damaging activity.

II. Formula Design and Blending

Formula R&D

Customizing formulas according to brand needs, such as adjusting probiotic strain ratios or adding humectants (e.g., hyaluronic acid) or antioxidants (e.g., Vitamin C).

Optimizing the formula through laboratory trials to ensure stability, solubility, and efficacy (e.g., whitening, anti-aging).

High-efficiency Blending and Sieving

Using professional blending equipment (such as V-type mixers) to deeply mix raw materials, ensuring uniform distribution of ingredients in every gram of powder.

Removing large particles through fine mesh screens to make the powder delicate and improve brewing solubility.

III. Core Stages of Freeze-drying Technology

Pre-freezing and Flash-freezing

Pre-freezing: Freezing the mixed powder at low temperatures (e.g., -40°C) to form a solid structure, preventing shape changes during sublimation.

Flash-freezing: Rapidly cooling to solidify moisture into tiny ice crystals, reducing damage to cell structures (such as preventing probiotic cell wall rupture).

Vacuum Sublimation Drying (Primary Drying)

In a vacuum environment (pressure below 10Pa), heat is provided via heating plates to cause ice crystals to sublime directly into water vapor, removing most free water.

Strictly controlling temperature (e.g., shelf temperature gradually rising from -40°C to 30°C) and vacuum levels to avoid ingredient inactivation or product collapse.

Desorption Drying (Secondary Drying)

Increasing the temperature (e.g., up to 45°C) to remove bound water, reducing product moisture content to below 3% to extend shelf life and prevent moisture absorption.

Determining the end of drying through pressure rise tests (e.g., closing the vacuum valve to observe pressure changes).

IV. Post-treatment and Packaging

Granulation and Filling

Processing the freeze-dried powder into small granules (optional step) to enhance solubility and stability, then filling into sachets or bottles using high-precision equipment.

Sealed packaging uses moisture-proof and anti-oxidation materials (such as aluminum foil bags); some products are filled with inert gas (such as nitrogen) to protect activity.

Quality Testing and Release

Testing items include:

Activity indicators: Probiotic live count, peptide content, enzyme activity, etc.

Physicochemical indicators: Moisture, pH, solubility, microbes (e.g., total plate count, pathogens).

Stability test: Observing changes in traits (e.g., layering, discoloration) after high/low temperature storage.

Qualified products are labeled (including production date, shelf life, usage instructions); unqualified products are reworked or destroyed.

V. Compliance and Registration Support

Regulatory Adherence

Ensuring products comply with target market regulations (e.g., China's "Cosmetic Supervision and Administration Regulation", EU EC No 1223/2009).

Cosmetics must complete filing (general products) or registration (special efficacy products), providing formulas, test reports, label samples, and other materials.

Intellectual Property Protection

Assisting brands in applying for trademarks and patents, protecting formulas and packaging designs, and avoiding infringement risks.

VI. Flexible Collaboration Models

One-stop Service

OEM manufacturers provide full-chain services from formula R&D and production to packaging design; brand owners only need to provide brand positioning and budget.

Supporting small-batch customization (e.g., MOQs from 5,000 bottles) to reduce inventory risk for brand owners.

Rapid Response and Iteration

Quickly adjusting formulas based on market feedback (e.g., consumer complaints regarding skin feel or efficacy), shortening product upgrade cycles (e.g., from 3 months to 1 month).

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